Spontaneous Enantiomeric Enrichment of Chiral 1- (1-Naphthyl) Ethylamine
Keywords:enantiomers, diastereomeric pairs, chiral resolving agents, chiral amines, chiral carboxylic acids, aminolysis and active pharmaceutical ingredients.
An aqueous solution of the reaction product R-(+)-1-(1-naphthyl)ethylamine hydrochloride, having high enantiomeric excess, was spontaneously resolved into the two enantiomers by simple crystallization to afford the product in nearly 100% ee.
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