The Role of K+, Ca2+ channels, Some Endothelium Hyperpolarizing Factors in Taurine Induced Vasorelaxation in Rats Aorta

Authors

  • Abdulsatar A. Haji Dept. of Biology, Faculty of Science, University of Zakho, Zakho, Kurdistan Region, Iraq
  • Omar A.M. Al-Habib College of Science, Nawroz University, Duhok, Kurdistan Region, Iraq

Keywords:

K channels, Ca2 channels, endothelium hyperpolarizing factors, aorta, taurine, vasorelaxation.

Abstract

The current study included the relaxant effect of taurine on rat’s aortic rings and the mechanism behind this relaxation. Taurine produced a potent spasmolytic effect on aortic rings at concentrations from zero to 80 mM. The results of K+ channel subtypes using specific blockers indicated that the Kv channel has a considerable role in taurine-induced relaxation, while KATP has a limited role, Exposure of aortic rings to combinations of two K+ blockers showed that KCa, Kv, and KIR play important role in taurine mediated relaxation. The endothelium-derived hyperpolarizing factors used showed responses to a variable extent in taurine mediated relaxation; since NO and cGMP played a major role whereas PGS played a minor role in taurine mediated relaxation. Finally, the results also indicated that taurine-mediated relaxation is endothelium-dependent.

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Published

2021-04-20

How to Cite

Haji, A. A., & Al-Habib, O. A. (2021). The Role of K+, Ca2+ channels, Some Endothelium Hyperpolarizing Factors in Taurine Induced Vasorelaxation in Rats Aorta . Technium BioChemMed, 2(1), 101–109. Retrieved from https://techniumscience.com/index.php/biochemmed/article/view/3234